Zero Trust has evolved over the last 15 years into a cornerstone of Federal cybersecurity strategy, influencing enterprises as well as State and Local Governments. While the principles of continuous authentication and least privilege are widely accepted, many organizations still need the industry’s support with implementation.
The National Institute of Standards and Technology’s (NIST) National Cyber Center of Excellence (NCCoE) has bridged this gap by offering practical guidance for applying Zero Trust concepts in real-world solutions.
Understanding Zero Trust Principles
Zero Trust is a cybersecurity strategy built on the assumption that networks are already compromised, making it the most resilient approach for securing today’s hybrid environments. Rather than relying on network perimeters, Zero Trust focuses on continuous authentication and verification of every access request, regardless of where those resources are located.
This approach requires organizations to secure all communications through encryption and authentication, grant access on a per-session basis with least privileges, implement dynamic policies, continuously monitor resource integrity and authenticate before allowing access. The objective is to reduce implicit trust between enterprise systems to minimize lateral movement by potential attackers.
Organizations must also collect and analyze as much contextual information as possible to create more granular access policies and strengthen current controls for an enhanced Zero Trust Architecture (ZTA).
NIST’s Role and Guidance
NIST has been instrumental in defining and operationalizing Zero Trust through guidance documents and practical demonstrations like Special Publication (SP) 800-207, published in 2020, which established the foundation for ZTA. Building on this framework, NIST’s NCCoE worked with industry, Government and academia to launch a project to show how these concepts could be implemented in real-world environments.
Initially focused on three example implementations, the project expanded to 19 different ZTA implementations using technologies from 24 industry collaborators, including Palo Alto Networks.
These implementations were built around three primary deployment approaches:
- Enhanced Identity Governance: Emphasizes identity and attribute-based access control, ensuring access decisions are linked to user identity, roles and context.
- Microsegmentation: Uses smart devices such as firewalls, smart switches or specialized gateways to isolate and protect specific resources.
- Software-Defined Perimeter (SDP): Creates a software overlay to protect infrastructure—like servers and routers—by concealing it from unauthorized users.
Although not included in SP 800-207, the project also recognized Secure Access Service Edge (SASE) as an emerging deployment model that integrates network and security functions into a unified, cloud-delivered service.
Practical Implementation Strategies

The NCCoE project tackled the critical question: where should organizations start on their Zero Trust journey? By adopting an agile, incremental approach with “crawl, walk and run” stages, the project phased its implementation based on deployment approaches. This allowed gradual, manageable builds while addressing real-world complexities.
Technologies such as firewalls, SASE with Software-Defined Wide Area Network (SD-WAN) and Endpoint Detection and Response (EDR) using Palo Alto Networks Cortex XDR® were utilized, with remote worker scenarios reflecting modern hybrid environments. NIST SP 1800-35 outlines the phased approach and provides a practice guide, including technologies, reference architectures, use cases, tested scenarios and security controls built into each implementation.
One of the most significant challenges addressed was interoperability between different security solutions. Rather than overhauling infrastructure, organizations can leverage existing technologies while gradually introducing new solutions to enhance security and move toward a mature ZTA.
Integrating Technology Solutions
The NCCoE highlighted how comprehensive security platforms enable Zero Trust principles across hybrid environments. Palo Alto Networks presented a comprehensive ZTA built with artificial intelligence (AI) and machine learning (ML), leveraging capabilities including Cloud Identity Engine for federated identity management, next-generation firewalls for microsegmentation, cloud-delivered security services and SASE for remote access and EDR.
The approach focused on three key objectives:
- Continuous trust verification and threat prevention
- Single policy enforcement across all environments
- Interoperability with other security solutions
AI was embedded throughout the platform—from policy creation to user and device analysis—ensuring that Zero Trust policies are enforced consistently and adapted automatically in response to evolving threats. This intelligent strategy provides a scalable and resilient foundation for securing modern, hybrid environments.
Community Collaboration and A Holistic Approach
The success of the NCCoE project underscored the importance of collaboration between Government and industry to develop practical Zero Trust solutions. This partnership enabled the development of a holistic security monitoring system that can track user behavior across on-premises, cloud and remote environments. The integration of AI and ML streamlined incident response, reducing mean time to detection and resolution.
Experts recommend that organizations begin their Zero Trust journey with fundamental capabilities such as identity and access management (ICAM), endpoint security and compliance and data security. Implementing multi-factor authentication (MFA), integrated with existing Active Directory (AD) systems or identity providers, is an effective first step in strengthening access security. Monitoring network traffic and endpoint behavior using threat intelligence, user behavior analytics and AI allows organizations to proactively detect and respond to threats, providing a solid foundation for a resilient ZTA.
The journey to operationalizing Zero Trust continues to evolve, with NIST planning updates to their guidance documents to address emerging technologies like SASE and special considerations for operational technology (OT) environments. By adopting the principles, frameworks and practical implementation approaches demonstrated through the NCCoE project, Government agencies can develop more resilient security architectures that protect resources across diverse environments.
To learn more about implementing ZTAs in Government environments, watch the full webinar “Operationalizing Zero Trust: NIST and End-to-End Zero Trust Architectures,” presented by Palo Alto Networks, NIST and Carahsoft.
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